There are several studies from 2012 to present showing that Cannabidiolic Acid aka CBDA, the acidic precursor of cannabidiol, (CBD) treats breast cancer, and inhibits cell migration of the highly-aggressive, triple-negative breast cancer MDA-MB-231.
Previous studies have found it works through the down-regulation of cyclooxygenase-2 (COX-2) and c-fos as well as interfering with AP-1 transcription. Current research shows that CBDA inhibits differentiation of ID1, a gene whose up-regulation is associated with cancer metastases and solid tumor growth.
Zhao Z, Bo Z, Gong W, Guo Y (2020). Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy. Int J Med Sci. 2020 Apr 6;17(8):995-1005.">2020
Pellati F, Borgonetti V, Brighenti V, Biagi M, Benvenuti S, Corsi L (2018). Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. Biomed Res Int.
Suzuki M, Takeda S, Okazaki H, Watanabe K, Takiguchi M, Aramaki H (2017). Cannabidiolic Acid-Mediated Interference with AP-1 Transcriptional Activity in MDA-MB-231 Breast Cancer Cells.Nat Prod Commun. 12(5):759-761.
Takeda S, Himeno T, Kakizoe K, Okazaki H, Okada T, Watanabe K, Aramaki H. (2017). Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. J Nat Med. Vol 71(1) Pp. 286-291.
Takeda S, Okazaki H, Ikeda E, Abe S, Yoshioka Y, Watanabe K, Aramaki H. (2014). Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells.
Takeda S (2013). Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis. Yakugaku Zasshi. Vol. 133(10) Pp. 1093-101. Review.
Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H (2012). Cannabidiolic acid, a major cannabinoid in
fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicology Letters. Vol 214(3) Pp. 314-9.