Cannabinoid Treatment for Glioma Brain Tumors (a 2020 review)

2개월 전

A 2020 scientific literature review of cannabinoids as treatment for glioma brain tumors, a type I had as a kid. This is a very important topic because conventional cancer treatment is deadly, especially for kids. It takes less than 100g of cannabis oil to treat most childhood cancers, but it takes a lifetime of cannabis oil after chemoradiation to treat its side long-term effects.


Bicker, J., Fortuna, A., Alves, G., & Falcão, A. (2020).
Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders
. Current pharmaceutical design, Vol. 26(5), 594–619.

Objective: Circumventing the lungs and blood brain barrier via intra-nasal administration of cannabinoids for glioblastoma and cerebrovascular disease.

Ellert-Miklaszewska, A., Ciechomska, I. A., & Kaminska, B. (2020). Cannabinoid Signaling in Glioma Cells. Advances in experimental medicine and biology, Vol 1202, pp. 223–241.

"Advances in translational research on cannabinoid signaling led to clinical investigations on the use of cannabinoids in treatments of [gliomas and] glioblastomas".

Hsu, K., Whitham, E., & Kichenadasse, G. (2020).
Potential role of cannabidiol for seizure control in a patient with recurrent glioma
. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 71, pp. 275–276.

A case study shows efficacy of cannabidiol (CBD) for seizure control in a glioma patients. Cannabis is promising for glioma patients for both tumor and seizure control.

Ivanov, V. N., Grabham, P. W., Wu, C. C., & Hei, T. K. (2020). Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Scientific reports, Vol. 10(1), pp. 2687.

"CBD was confirmed as a powerful inducer of autophagy 6 h after treatment of U87MG GBM [glioblastoma] cells".

Kenyon, J., Liu, W., & Dalgleish, A. (2018). Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol. Anticancer research, Vol. 38(10), pp. 5831–5835.


"Clinical responses [of CBD] were seen in 92% of the 119 cases with solid tumours including a reduction in circulating tumour cells in many cases and in other cases, a reduction in tumour size, as shown by repeat scans. No side-effects of any kind were observed...".


Above: 5-year-old boy with no more treatment options shows 60% reduction in (anaplastic ependymoma) brain tumor growth in less than a year

Luís, Â., Marcelino, H., Rosa, C., Domingues, F., Pereira, L., & Cascalheira, J. F. (2020). The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies. European journal of pharmacology, 876, 173055.

Rosewall, T., Feuz, C., & Bayley, A. (2020). Cannabis and 1. Radiation Therapy: A Scoping Review of Human Clinical Trials. Journal of medical imaging and radiation sciences, S1939-8654(20)30007-2. Advance online publication.

A fluff piece stating that cannabinoids help glioma patients treat radiation-induced anxiety and side effects, without talking about how they improve radiosensitivity of glioma patients undergoing radiation.

Santoni, G., Amantini, C., Maggi, F., Marinelli, O., Santoni, M., Nabissi, M., & Morelli, M. B. (2020). The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature. Laboratory investigation; a journal of technical methods and pathology, Vol. 100(2), pp. 186–198.

Overexpression of TRPV2 vanilloid receptor (a less commonly known part of the Endocannabinoid system) is observed in many types of aggressive cancer, including temozolomide-resistant glioblastoma, and may be a therapeutic target.
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