Chloroquine improves survival and hematopoietic recovery following lethal low dose- rate radiation

10개월 전

I thought I would post this info here to inform everyone who is interested in knowledge. Considering the climate of our political environment, this is a very interesting study, with very important possible ramifications..

Chloroquine improves survival and hematopoietic recovery following lethal low dose- rate radiation

Chloroquine protects mice from LDR radiation induced death
We were similarly interested in understanding the effects of chloroquine in animals treated with the drug prior to total body exposure to LDR. To examine whether similar radio-protective effects can be induced in vivo, we treated normal mice with chloroquine prior to LDR irradiation. Compared to untreated animals (n=19), mice pre-treated with two doses of chloroquine (n=24) demonstrated significantly improved survival rates (Fig. 2A, 31% vs. 80%, p=0.0026).

Conclusion
Chloroquine administration prior to radiation had a significant effect on the survival of normal but not ATM null mice strongly suggesting that the in vivo effect like the in vitro effect is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection against the harmful effects of LDR radiation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388169/

So that is a study on NIH. It makes me very curious indeed...Given our environment. On other factors besides the 'virus'.

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