Where PO2 artery blood is reduced. Hypoxic hypoxia is a hypoxic state caused by lack of oxygen entering the lungs so that oxygen can not reach the blood and fail to enter the blood circulation. This failure can be caused by obstruction or obstruction in the respiratory tract, either by natural causes (eg disease accompanied by respiratory tract obstruction such as diphtheria laryngitis, asthmatic status, carcinoma and so on) or by mechanical trauma or violence, such as airway obstruction, choking, hanging, drowning and so on.
Where arterial blood PO2 is normal but the amount of hemoglobin available to transport oxygen is reduced, as in carbon monoxide poisoning because the CO affinity for hemoglobin is much higher than that of oxygen affinity with hemoglobin.
Hypoxia stagnant is a hypoxic state caused by blood (hemoglobin) is unable to carry oxygen to the tissues due to circulatory failure such as heart failure or embolism, both venous air embolism and fat embolism even though PO2 is normal hemoglobin concentration.
Where the amount of oxygen delivered to a tissue is adequate but due to the action of substances toxic tissue cells can not use the oxygen provided, for example in cyanide poisoning. Cyanide in the body will activate some radical tissue oxidative enzymes radically especially cytochrome oxidase by binding to the ferricheme group part of the blood-borne oxygen. Thus, the oxidation-reduction process in the cell can not take place and oxyhemoglobin can not dissociate release of oxygen to tissue cells resulting in tissue hypoxia. This is a paradoxical condition, because the victim dies cyanide poisoning hypoxia though in his blood rich in oxygen.
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