Despite the existence of many host defense mechanisms, bacterial pathogens have developed a wide range of human organ colonization and invasion strategies. In this review, I will explain how pathogenic bacteria bind and multiply in the host's cells, how certain bacteria penetrate and spread to these cells and, finally, how pathogens cross the host's epithelial or endothelial barrier.
An internal organization that causes serious illness in humans. There are many bacteria in the human body, but in healthy people, their location is generally limited to certain parts of the body, such as the skin and mucous membranes of the mouth and nose, the vagina and, most importantly, the digestive system.
The internal tissues are generally sterile. However, in some cases, certain opportunistic pathogens can infect the host with infections or overcome one of the host's various barriers.
Well-intentioned pathogens have also developed the owner's reproductive mechanisms and dangerous diseases to overcome deeper barriers and reach deeper organs. In this review, we will study the various mechanisms by which bacterial pathogens are used to colonize and invade human organs.
First, although the host uses different defense mechanisms, we focus on the ability of these bacteria to bind and multiply through the host's cells and tissues. Next, we'll look at how some bacteria infiltrate and spread to host cells. Finally, we discuss how pathogens penetrate deeper tissues as they cross the maternal barrier, increasing their spread among guests.
The area of the gastrointestinal tract and the urogenital system that makes up the respiratory system is about 300-400 square meters (200 times the surface of the skin), so it is the most important point of contact with bacteria. It consists of three layers: the epithelium, a layer of soft connective tissue called the lamina propria and a thin layer of smooth muscle.
These surfaces form boundary barriers that limit the invasion of primary and pathogenic bacteria. Although there are several defense mechanisms at the level of these barriers, pathogenic bacteria have developed a series of molecular strategies that bind to the epithelial E and proliferate on the surface.